Archive for October 2014

Noninvasive Cardiac Output | Data Acquisition

Noninvasive Cardiac Output (NICO) measures can be determined by employing electrical bioimpedance (EBI) measurement techniques. Electrical bioimpedance is the characteristic impedance of a volume of tissue and fluid. For Cardiac Output measures, the relevant tissue includes the heart and the immediate surrounding volume of the thorax, and the relevant fluid is blood.
The electrical impedance of the thorax (Zt) can be thought of as composed of two impedance types:
  1. The base impedance (Zo) corresponding to non-time varying tissues, such as muscle, bone and fat. Zo is measured when the pulsatile volume is minimal.
  2. The delta impedance (dZ) corresponding to time-varying fluid volume (blood).
http://www.biopac.com/noninvasive-blood-pressure-amplifier-nibpZt drops with each pulsatile volume of blood ejected from the heart. dZ/dt is the magnitude of the largest impedance change during systole.
Noninvasive cardiac output amplifiers incorporate a precision high-frequency current source, which injects a very small (400 microamp rms) current through the measurement tissue volume defined by the placement of a set of current source electrodes. A separate set of monitoring electrodes measures the voltage developed across the tissue volume. Because the current is constant, the voltage measured is proportional to the characteristics of the biological impedance of the tissue volume.
BIOPAC data acquisition hardware for recording real-time Noninvasive Cardiac Output parameters include tethered amplifiers such as the NICO100C (or NICO100C-MRI for fMRI environments), EBI100C, or SS31L, or the wireless BioNomadix BN-NICO.
Hardware simultaneously measures impedance magnitude and phase, and may incorporate an internal derivative function to output dZ/dt simultaneously with Z; an AcqKnowledge calculation channel can also be used to determine dZ/dt. The internal derivative function inverts the polarity of the dZ/dt signal so that it displays a positive-going peak, coincident with negative slopes indicated in Z, as per academic research convention.
Disposable Ag/AgCl Paired Electrodes (EL500) are recommended for bioimpedance and cardiac output studies. Paired electrodes provide fixed spacing between the dual contacts and are pre-gelled with hypo-allergenic, wet liquid gel electrolyte (10% chloride salt); the gel cavity is situated between electrode and skin surfaces and helps reduce motion artifact.
The impact of movement artifacts on recorded data is a significant methodological concern in impedance cardiography; Ensemble Averaging tools in AcqKnowledge provide an automated strategy to remove these artifacts. Watch a demo now!

Data Hardware & Software Platforms

Data acquisition hardware and software requirements vary widely based on experiment protocol, classroom setup, field studies, etc. BIOPAC data acquisition hardware platforms support wired, wireless, and fMRI setups, for human or animal subjects, with powerful, intuitive data software for research and teaching applications. Use with a variety of amplifiers, stimulators, triggers, transducers, gas analysis modules, and/or electrodes to acquire life science signals, including ECG, EEG, EOG, EMG, EGG, EDA, Respiration, Pulse, Temperature, Impedance Cardiography, Force, Accelerometry, Goniometry, Dynamometry, Gyro, and more. Combine data hardware for multi-subject or multi-parameter protocols.

Research hardware platforms are fully-integrated with AcqKnowledge® data acquisition software, which provides automated routines for data scoring, measurement, and reporting, and can support multiple hardware units. Teaching platforms include Biopac Student Lab software with media-rich tutorial style guide lessons for specified objectives, plus active learning options for student-designed experiments and advanced analysis.

Wired (tethered) data acquisition hardware platforms include the MP150 and MP36R Research Systems. The MP150 16-channel system with universal amplifier provides high resolution (16 bit), high-speed acquisition (400 kHz aggregate) with16 analog inputs and two analog outputs, digital I/O lines (to automatically control other TTL level equipment), and online calculation channels. The MP36R 4-channel research system with built-in amplifiers provides four analog inputs and one analog output, I/O port for digital devices, calculation channels, trigger port, headphone jack, and electrode impedance checker. The MP36R supports software-controlled amplifiers and calculation channels.

Wireless data hardware includes options for live or logged data:
BioNomadix wireless, wearable physiology monitoring devices noninvasively record high-quality, full-bandwidth data while comfortably allowing subjects to move freely in natural indoor environments. Digital transmission and transducers placed close to the signal source provide excellent signal quality. Record up to 16 channels of BioNomadix data with a BIOPAC MP150 System—the system also works with multiple MP150 systems or third-party data acquisition hardware via an isolated power supply module. 

Mobita® 32-channel wearable wireless systems are ideal for biopotential applications that demand subject mobility and data logging. The Mobita EEG System uses water electrodes—no skin prep or gels required. Record live data into AcqKnowledge or log to an internal storage card for later upload into AcqKnowledge; modes are easily switched to suit specific protocols.

B-Alert X10® Wireless Systems provide nine channels of high fidelity EEG plus ECG, and data software for cognitive state metrics software is available. The stand-alone system easily interfaces with MP150 Research System to synchronize with other physiological data.

BioHarness® with AcqKnowledge is a lightweight, non-restrictive data logger and telemetry system to monitor, record, and analyze a variety of physiological parameters, including ECG, respiration, posture, and acceleration.

Stellar® Small Animal Telemetry Licenses with AcqKnowledge control wireless data acquisition from Stellar Implantable Telemetry Systems. The easy-to-configure Animal Scheduler works for a subset or complete group of conscious, unrestrained small animals for long term recordings. Multiple display modes can be viewed simultaneously, and signal conditioning tools (e.g., filtering and artifact removal) can be applied.


These and other BIOPAC data hardware and software solutions are used in thousands of labs worldwide and cited in thousands of publications. Learn more about research systems and teaching systems.

Biomechanics Transducers | Data Acquisition

Biomechanics data can include measures of force and motion of body position, posture, and joint movement over a wide range of static and dynamic conditions. Biomechanics measurements are meaningful for a wide variety of research applications, such as biomedical engineering, exercise physiology, sports training or rehab, and ergonomics (for characteristics of a specific work activity or environment). 

Biomechanics transducers include goniometers, torsiometers, and accelerometers. Transducers are unobtrusive and lightweight, and can be worn comfortably and undetected under clothing or attached to external equipment—leaving the subject to move freely in the normal environment.
Biomechanics transducers connect directly to the BIOPAC Acquisition Unit as part of an MP or BSL System. For a more complete physiological analysis, additional signals can be recorded (e.g., EMG, respiration, heart rate) and video data can be tightly-synchronized for a clear and detailed view of the biomechanics of a movement with the subject’s physiological data.



Goniometers incorporate gauge elements that measure bending strain along or around a particular axis and transform angular position into a proportional electrical signal. The gauge mechanism allows for accurate measurement of polycentric joints. As the joint moves through a determined angle, the relative linear distance between the two mounting positions will change. A telescopic endblock prevents the measuring element from becoming over-stretched or buckled as the limb moves. The bending strain is proportional to the sum total angular shift along the axis. Because the bending force is extremely small, the output signal is uniquely a proportional function of the angular shift.


Twin-axis goniometers measure rotation about two orthogonal planes simultaneously to record limb angular movement, such as adequate bending in the elbows or knees, unsafe rounding in the lower spine, wrist or ankle flexion/extension, abduction/adduction, radial/ulnar deviations, etc. Single-axis goniometers measure the angle in one plane only and are used to record digit joint movement of fingers, thumb or toes.
Torsiometers measure rotation about a single axis (e.g., forearm pronation/supination) to record angular twisting (as opposed to bending) of the torso, spine or neck.

Tri-Axial Accelerometers are high level output transducers that provide three outputs to measure acceleration along the X-, Y- and Z-axes simultaneously. To reliably record head tilt, place an accelerometer on the head. To measure accelerations when performing slow movements, such as walking and hand tremor, ±5 G accelerometers are optimal; ±50 G are more suitable for quick movements, such as swinging a tennis racket.
For applications where quick or rapid movements are involved, fit a “sock” bandage over the whole sensor and interconnect lead. For accurate results from long recordings, use double-sided adhesive between the endblocks and skin, and place single-sided adhesive tape over the top of the endblocks. No tape should come into contact with the spring. The connection lead should also be taped down near the sensor element.

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